O 38.6 in team 2 (p = 0.sixty four). Median APACHE II scores have been identical and length of cardiovascular support was not considerably distinct concerning the two groups. Length of ICU remain (median [interquartile PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21046519 range]) was longer in group 2 at 6 times [3-12] as opposed to 3 [1-7] (p < 0.001) however this significance was lost when non-survivors were excluded. There was a significantly lower requirement for RRT amongst ICU survivors in group 2 at 15.7 compared to 34 (p = 0.0078). Conclusions: We have shown a significant improvement in rate of RRT associated with implementation of our sepsis resuscitation bundle. Whilst implementation of care bundles has been associated with improved patient outcome, the basis of this relationship remains unclear [2]. Our work fails to demonstrate a significant reduction in mortality however we acknowledge the limitations of a small sample size. Median bundle compliance is higher than in other published work [2] however ongoing quality improvement work may increase this further. We identified a longer length of stay in group 2. This may represent either a longer period of treatment before deciding to change the focus of care to palliation or a faster decline in patients within group 1.References 1. Dellinger et al.: Crit Care Med 2004; 32: 858-73 2. Levy et al.: Intensive Care Med 2010; 36: 222-P048 Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock P. Szturz 1, P. Folwarzcny1, J. Svancara2, R. Kula1, P. Sevcik1 1 University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic; 2Institute of Biostatistics and analyses, Masaryk University, Brno, Czech Republic Critical Care 2016, 20(Suppl 2):P048 Introduction: Vasopressor therapy is required to sustain life and maintain perfusion in the face of life-threatening hypotension occurring with severe sepsis and septic shock, even when hypovolemia has not yet been resolved. [1] We hypothesized that a dose of norepinephrine administered in the first 24 hours correlates with the outcome of treatment in patients with PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/18111632 intense sepsis and septic shock. Techniques: We analysed a total of 632 consecutive people with septic shock (sepsis-induced hypotension persisting irrespective of ample fluid resuscitation) from the EPOSS databases (Data-based Analysis and Prediction of End result in Serious Sepsis), which was developed to observe and assess the treatment efficacy in clients with significant sepsis and septic shock. Sufferers had been admitted to collaborating intensive care units (twelve hospitals ?seventeen high-volume care models) from the Czech Republic from 1st of January 2011 to fifth of November 2013. The sufferers had been divided into two teams: survivors (n = 316) and nonsurvivors (n = 316). Results: The groups of survivors vs. nonsurvivors were similar in: age 66.0 (39.0; eighty four.0) vs. 68.0 (34.0;86.0) p = 0.162, gentlemen 184 (fifty eight.two ) vs. 190 (60.1 ) p = 0.343, APACHE II rating 26.0 (fourteen.0; 39.0) vs. 28.0 (14.0; forty.0) p = 0.565 and the Letrozole Sofa score ten.0 (4.0 ?16.0) vs. ten.0 (three.0 ?sixteen.0) p = 0.912. Administration on the dose of thirty mL/kg of crystalloids for hypotension or lactate 4 mmol/L (three hrs) and application of vasopressors (6 several hours) was executed in both equally groups, without the need of statistically major variances. Statistically substantial differences amongst survivors vs. nonsurvivors had been identified inside the parameter “Dose of norepinephrine during the very first 24 hours”, 0.211 (0.022 – 1.104).
O 38.six in group two (p = 0.sixty four). Median APACHE II scores have been equivalent and
